Observational study reporting (lite) — v1.0.0

Released: 2026-02-02 · Hash: sha256:0cf1d935cb14756602a6ae0ba10b6c569fa14fdd7b062abd3831433ea8eb1073

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Title & Abstract
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must OBS-01Make the study design explicit (e.g., cohort/case-control/cross-sectional) in the title or abstract.
should OBS-02Abstract summarizes objectives, setting, participants, exposures/predictors, outcomes, key analyses, and main results with quantitative estimates.
Introduction
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must OBS-10State the scientific background and the specific objectives (and prespecified hypotheses, if any).
Methods
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must OBS-20Describe the key elements of the study design early, including the setting, locations, and relevant dates (recruitment, exposure window, follow-up, data collection).
must OBS-21Describe participant eligibility criteria and selection methods (and follow-up procedures, if applicable).
must OBS-22Define all key variables: outcomes, exposures, predictors, confounders, and effect modifiers; include diagnostic criteria where relevant.
should OBS-23Describe data sources and measurement methods for each variable, including efforts to ensure comparability across groups.
should OBS-24Describe steps taken to identify and reduce potential biases (selection, information, confounding).
should OBS-25Explain the study size rationale (sample size, precision targets, feasibility constraints, or available data).
must OBS-26
Describe statistical methods, including confounding control, subgroup/interaction analyses (if any), missing data handling, and sensitivity/robustness checks.
Results
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must OBS-30Report participant numbers at each stage (eligible, included, analyzed) and reasons for non-participation; include a flow diagram if helpful.
must OBS-31
Provide participant descriptive data (key demographics/clinical variables) and indicate missingness for key variables.
must OBS-32Report outcome event counts or summary measures over time (as applicable), with denominators.
must OBS-33Report main effect estimates with measures of precision (e.g., confidence intervals) and clarify which confounders were adjusted for.
may OBS-34Report additional analyses (e.g., subgroup analyses, alternative model specifications, sensitivity analyses) with rationale.
Discussion
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must OBS-40Discuss key limitations and potential sources of bias (direction and likely magnitude where feasible).
should OBS-41Provide an overall interpretation in the context of evidence and discuss generalisability (external validity).
Other
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must OBS-50Disclose ethics approval/consent (if applicable), funding and competing interests, and provide a data/code availability statement.